Chronic, severe pain which cannot be related to any specific injury or disease process in the body is becoming increasingly common, and the management of such pain has proven elusive. Good results, however, have been gained by using immunoglobulin concentrated from bovine colostrum and given intravenously, though the exact mechanism of why this treatment works is as yet unknown.
Immunoglobulins pooled from bovine colostrum have been used intravenously for the treatment of chronic pain without anatomical correlate.

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